Mutagenicity Detection Method for Vinyl Chloride and Vinylidene Chloride Gases.
نویسندگان
چکیده
منابع مشابه
Inhalation toxicity of vinyl chloride and Vinylidene chloride*
Exposure of mice to 1000 ppm of vinyl chloride (VC), 6 hr/day, 5 days/week, caused some acute deaths with toxic hepatitis and marked tubular necrosis of the renal cortex. Starting the sixth month, mice exposed to 1000, 250, or 50 ppm of VC became lethargic, lost weight quickly, and died. Only a few mice exposed to 50 ppm survived for 12 months. Pulmonary macrophage count was elevated in some mi...
متن کاملMutagenicity studies of vinyl chloride.
Mutagenicity studies in both man and in test organisms clearly demonstrate positive mutagenic activity of vinyl chloride. In terms of the mutagenicity studies using a variety of in vitro procedures covering both eukaryotes and prokaryotes, positive effects were found. Cytogenetic in vivo studies in animals and in humans indicate not only somatic mutations, but also germinal effects with this ch...
متن کاملMutagenicity and metabolism of vinyl chloride and related compounds.
The various adverse biological effects of vinyl chloride appear to be dependent upon the metabolic conversion of this compound into chemically reactive metabolites. The metabolism of vinyl chloride in mammals and in man, including the formation of monochloroacetic acid and some identified sulfur conjugates is reviewed. Hepatic microsomal mixed function oxidases from rats, mice, and humans were ...
متن کاملComparative mammalian metabolism of vinyl chloride and vinylidene chloride in relation to oncogenic potential.
Elucidation of the role of vinyl chloride metabolites in the various reaction sequences which comprise the metabolic pathway, including the interaction of reactive metabolities with some purine and pyrimidine residues of target-organ DNA, provides some explanation for the (oncogenic) properties associated with the original substance. Comparative investigation of the biological fate of vinyliden...
متن کاملPharmacokinetics of vinylidene chloride.
Dear Sir: The recent article by McKenna et al. (1) on phar-macokinetics of vinylidine chloride (VDC) in the rat has evoked a number of thoughts. These relate both to one detail of data presentation from the excellent experimental studies and to the general role of pharmacokinetics in supporting risk assessment from high dose studies in mammals. The detail concerns Figure la (Figure 2 of the McK...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Environmental Chemistry
سال: 1995
ISSN: 1882-5818,0917-2408
DOI: 10.5985/jec.5.235